| Issue Date |
Song |
Artist |
| January 7 |
"Run It!" |
Chris Brown |
| January 14 |
"Run It!" |
Chris Brown |
| January 21 |
"Run It!" |
Chris Brown |
| January 28 |
"Stickwitu" |
Pussycat Dolls |
| February 4 |
"Stickwitu" |
Pussycat Dolls |
| February 11 |
"Check on It" |
Beyoncé featuring Slim Thug |
| February 18 |
"Check on It" |
Beyoncé featuring Slim Thug |
| February 25 |
"Check on It" |
Beyoncé featuring Slim Thug |
| March 4 |
"Check on It" |
Beyoncé featuring Slim Thug |
| March 11 |
"Check on It" |
Beyoncé featuring Slim Thug |
| March 18 |
"Check on It" |
Beyoncé featuring Slim Thug |
| March 25 |
"So Sick" |
Ne-Yo |
| April 1 |
"Be Without You" |
Mary J. Blige |
| April 8 |
"Be Without You" |
Mary J. Blige |
| April 15 |
"Be Without You" |
Mary J. Blige |
| April 22 |
"Be Without You" |
Mary J. Blige |
| April 29 |
"Temperature" |
Sean Paul |
| May 6 |
"Temperature" |
Sean Paul |
| May 13 |
"SOS" |
Rihanna |
| May 20 |
"Temperature" |
Sean Paul |
| May 27 |
"Hips Don't Lie" |
Shakira featuring Wyclef Jean |
| June 3 |
"Hips Don't Lie" |
Shakira featuring Wyclef Jean |
| June 10 |
"Hips Don't Lie" |
Shakira featuring Wyclef Jean |
| June 17 |
"Hips Don't Lie" |
Shakira featuring Wyclef Jean |
| June 24 |
"Hips Don't Lie" |
Shakira featuring Wyclef Jean |
| July 1 |
"Hips Don't Lie" |
Shakira featuring Wyclef Jean |
| July 8 |
"Hips Don't Lie" |
Shakira featuring Wyclef Jean |
| July 15 |
"Promiscuous" |
Nelly Furtado featuring Timbaland |
| July 22 |
"Promiscuous" |
Nelly Furtado featuring Timbaland |
| July 29 |
"Promiscuous" |
Nelly Furtado featuring Timbaland |
| August 5 |
"Promiscuous" |
Nelly Furtado featuring Timbaland |
| August 12 |
"Promiscuous" |
Nelly Furtado featuring Timbaland |
| August 19 |
"Promiscuous" |
Nelly Furtado featuring Timbaland |
| August 26 |
"Promiscuous" |
Nelly Furtado featuring Timbaland |
| September 2 |
"Promiscuous" |
Nelly Furtado featuring Timbaland |
| September 9 |
"Buttons" |
Pussycat Dolls featuring Snoop Dogg |
| September 16 |
"Buttons" |
Pussycat Dolls featuring Snoop Dogg |
| September 23 |
"SexyBack" |
Justin Timberlake |
| September 30 |
"SexyBack" |
Justin Timberlake |
| October 7 |
"SexyBack" |
Justin Timberlake |
| October 14 |
"SexyBack" |
Justin Timberlake |
| October 21 |
"SexyBack" |
Justin Timberlake |
| October 28 |
"Far Away" |
Nickelback |
| November 4 |
"Far Away" |
Nickelback |
| November 11 |
"Lips of an Angel" |
Hinder |
| November 18 |
"Lips of an Angel" |
Hinder |
| November 25 |
"Lips of an Angel" |
Hinder |
| December 2 |
"My Love" |
Justin Timberlake featuring T.I. |
| December 9 |
"My Love" |
Justin Timberlake featuring T.I. |
| December 16 |
"My Love" |
Justin Timberlake featuring T.I. |
| December 23 |
"My Love" |
Justin Timberlake featuring T.I. |
| December 30 |
"Irreplaceable" |
Beyoncé |